1819 Oak Dr, Hamilton, NY 13346, USA

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Eric Alani, professor of genetics, Cornell University will be our guest speaker.

Roles for DNA mismatch repair proteins in promoting fertility 

My laboratory studies highly conserved mismatch repair (MMR) systems, which act to repair mismatches that arise as the result of DNA replication errors, DNA damage, and genetic recombination.  Components in these systems also function to promote meiotic crossing over, a process critical for the proper segregation of homologous chromosomes in meiosis. In humans, mutations in MMR genes are linked to predisposition to a hereditary form of colorectal cancer and infertility, underscoring the importance of obtaining new mechanistic understandings of MMR systems. My talk will cover our studies aimed at identifying mechanistic roles in meiotic crossing over for the DNA mismatch repair factors Exo1 and Mlh1-Mlh3. 

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